Neuroscience as The Foundamental

Neuroscience
• How do brains process information? 



Neuroscience is the study of the nervous system, particularly the brain. Although the exact way in which the brain enables thought is one of the great mysteries of science, the fact that it does enable thought has been appreciated for thousands of years because of the evidence that strong blows to the head can lead to mental incapacitation. It has also long been known that human brains are somehow different; in about 335 B.C. Aristotle wrote, “Of all the animals, man has the largest brain in proportion to his size.”5 Still, it was not until the middle of the 18th century that the brain was widely recognized as the seat of consciousness. Before then, candidate locations included the heart and the spleen. Paul Broca’s (1824–1880) study of aphasia (speech deficit) in brain-damaged patients in 1861 demonstrated the existence of localized areas of the brain responsible for specific cognitive functions. In particular, he showed that speech production was localized to the portion of the left hemisphere now called Broca’s area.6 By that time, it was known that the brain consisted of nerve cells, or neurons, but it was not until 1873 that Camillo Golgi (1843–1926) developed a staining technique allowing the observation of individual neurons in the brain (see Figure 1.2). This technique was used by Santiago Ramon y Cajal (1852– 1934) in his pioneering studies of the brain’s neuronal structures.7 Nicolas Rashevsky (1936, 1938) was the first to apply mathematical models to the study of the nervous sytem.

We now have some data on the mapping between areas of the brain and the parts of the body that they control or from which they receive sensory input. Such mappings are able to change radically over the course of a few weeks, and some animals seem to have multiple maps. Moreover, we do not fully understand how other areas can take over functions when one area is damaged. There is almost no theory on how an individual memory is stored. The measurement of intact brain activity began in 1929 with the invention by Hans Berger of the electroencephalograph (EEG).

The recent development of functional magnetic resonance imaging (fMRI) (Ogawa et al., 1990; Cabeza and Nyberg, 2001) is giving neuroscientists unprecedentedly detailed images of brain activity, enabling measurements that correspond in interesting ways to ongoing cognitive processes. These are augmented by advances in single-cell recording of neuron activity. Individual neurons can be stimulated electrically, chemically, or even optically (Han and Boyden, 2007), allowing neuronal input– output relationships to be mapped. Despite these advances, we are still a long way from understanding how cognitive processes actually work.

The only real alternative theory is mysticism: that minds operate in some mystical realm that is beyond physical science. Brains and digital computers have somewhat different properties. Figure 1.3 shows that computers have a cycle time that is a million times faster than a brain. The brain makes up for that with far more storage and interconnection than even a high-end personal computer, although the largest supercomputers have a capacity that is similar to the brain’s. (It should be noted, however, that the brain does not seem to use all of its neurons simultaneously.) Futurists make much of these numbers, pointing to an approaching singularity at which computers reach a superhuman level of performance (Vinge, 1993; Kurzweil, 2005), but the raw comparisons are not especially informative. Even with a computer of virtually unlimited capacity, we still would not know how to achieve the brain’s level of intelligence.


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